The Lacuna Project

lacuna (n.) a gap in a record where something should be

Independent research. Not affiliated with any government, agency, or company.

University

University of Pennsylvania

Findings that rest on exhibits naming this entity

  • AGR-1.9: Sodium carboxymethylcellulose is listed in FDA's regulations as generally recognized as safe when used in accordance with good manufacturing practice (21 CFR 182.1745). In a double-blind controlled-feeding study of 16 healthy adults, 15 g per day of carboxymethylcellulose for 11 days reduced gut microbiota diversity and changed the fecal metabolome relative to controls, and the study reported no disease outcome.

Exhibits naming this entity

  • Exhibit 566 November 2021 (online); March 2022 (print). Chassaing B, Compher C, Bonhomme B, et al. (Penn State; University of Pennsylvania; INSERM/Universite Paris Cite; others): Randomized Controlled-Feeding Study of Dietary Emulsifier Carboxymethylcellulose Reveals Detrimental Impacts on the Gut Microbiota and Metabolome (Gastroenterology 162:743-756)