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Exhibit 112

Historical Vaccine Safety Concerns: Simian virus 40

Exhibit 112 · Agency web page

Historical Vaccine Safety Concerns: Simian virus 40

From 1955 to 1963, an estimated 10-30% of polio vaccines administered in the US were contaminated with simian virus 40 (SV40).

CDC states that from 1955 to 1963 an estimated 10–30% of polio vaccines administered in the United States were contaminated with SV40, mostly inactivated vaccine but also oral vaccine. It states that after the contamination was discovered the government set testing requirements to verify that all new lots were free of SV40, that most studies are reassuring and find no causal association with cancer, and that no vaccine used today contains SV40.

Source
Centers for Disease Control and Prevention
Date
Current page, accessed 2026
Quoted from
CDC 'Historical Vaccine Safety Concerns', section 'Simian Virus 40 (SV40): 1955 - 1963', paragraph 1
Grade
Primary record
Document
https://www.cdc.gov/vaccine-safety/historical-concerns/
Accessed
2026-11-09
Cited by
Findings citing this exhibit

Cited by

Finding MED-7.2
Reported Federal officials knew by 1960 that polio vaccine carried SV40. They ordered new lots screened in 1961, recalled no existing stock, and certified every lot free of the virus only from 1963.
Finding MED-7.3
Primary record CDC has estimated that 10 to 30 million Americans may have received polio vaccine contaminated with SV40.