Exhibit 191 · Research article
HPV Vaccination and the Risk of Invasive Cervical Cancer
After adjustment for all covariates, the incidence rate ratio was 0.12 (95% CI, 0.00 to 0.34) among women who had been vaccinated before the age of 17 years and 0.47 (95% CI, 0.27 to 0.75) among women who had been vaccinated at the age of 17 to 30 years.
Swedish registry cohort of 1,672,983 girls and women aged 10 to 30, followed from 2006 to 2017. Cumulative incidence of invasive cervical cancer was 47 per 100,000 among the vaccinated and 94 per 100,000 among the unvaccinated. The adjusted incidence rate ratio was 0.12 for vaccination before age 17 and 0.47 for vaccination at ages 17 to 30. The vaccine was quadrivalent.
- Source
- Lei et al., New England Journal of Medicine 383: 1340–1348
- Date
- 1 October 2020
- Quoted from
- Abstract, Results
- Grade
- Peer-reviewed
- Document
- https://www.nejm.org/doi/full/10.1056/NEJMoa1917338
- Accessed
- 2026-11-09
- Cited by
- Findings citing this exhibit
- Note
- Observational design.