The Lacuna Project

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Exhibit 016

The introduction of DTP and OPV among children in urban Guinea-Bissau

Exhibit 016 · Natural experiment

The introduction of DTP and OPV among children in urban Guinea-Bissau

Among 3–5-month-old children, having received DTP (± OPV) was associated with a mortality hazard ratio (HR) of 5.00 (95% CI 1.53–16.3) compared with not-yet-DTP-vaccinated children.

Vaccination timing was set by birthday relative to quarterly weighing sessions. Infants aged three to five months who had received DTP died at five times the rate of not-yet-vaccinated infants (HR 5.00, 95% CI 1.53–16.3), based on 11 and 5 deaths.

Source
Mogensen et al., EBioMedicine
Date
2017
Quoted from
Abstract, Results; Table 3 gives 11 deaths (DTP) vs 5 (unvaccinated)
Grade
Peer-reviewed
Document
https://pmc.ncbi.nlm.nih.gov/articles/PMC5360569/
Accessed
2026-11-09
Cited by
Findings citing this exhibit

Cited by

Finding MED-3.7
Open question Studies of 1980s data from Guinea-Bissau found higher infant mortality after DTP vaccination, and no randomized trial has tested the finding.