Exhibit 157 · Animal carcinogenicity study
Carcinogenic effects of long-term exposure from prenatal life to glyphosate and glyphosate-based herbicides in Sprague–Dawley rats
Most of these involved tumors that are rare in SD rats (background incidence < 1%) with 40% of leukemias deaths in the treated groups occurring before 52 weeks of age
Male and female Sprague–Dawley rats were given glyphosate, Roundup BioFlow or RangerPro in drinking water from gestational day 6 to 104 weeks of age, at 0.5 mg/kg/day (the EU acceptable daily intake), 5 mg/kg/day and 50 mg/kg/day (the EU no-observed-adverse-effect level). In all three dose groups the authors observed statistically significant dose-related trends or increased incidences of benign and malignant tumors at multiple sites, including leukemia, liver, thyroid, nervous system, mammary gland and kidney, in both sexes. Most were tumors rare in this strain (background incidence under 1 percent), and 40 percent of leukemia deaths in treated groups (6 of 15 leukemia-bearing animals) occurred before 52 weeks of age.
- Source
- Simona Panzacchi et al., Ramazzini Institute (Global Glyphosate Study); Environmental Health 24:36
- Date
- 10 June 2025
- Quoted from
- Abstract, Results (Environ Health 24:36)
- Grade
- Peer-reviewed
- Document
- https://doi.org/10.1186/s12940-025-01187-2
- Accessed
- 2026-11-09
- Cited by
- Findings citing this exhibit
- Note
- The study has not been independently replicated.