The Lacuna Project

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Exhibit 605

Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association

Exhibit 605 ยท Scientific advisory

Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association

replacement of saturated fat with mostly refined carbohydrates and sugars is not associated with lower rates of CVD and did not reduce CVD in clinical trials

American Heart Association advisory reviewing randomized trials and prospective cohorts. States that trials that lowered saturated fat and replaced it with polyunsaturated vegetable oil reduced CVD by about 30 percent, and that replacement with mostly refined carbohydrates and sugars is not associated with lower CVD rates.

Source
Sacks FM, Lichtenstein AH, Wu JHY, et al.; Circulation 136(3):e1-e23
Date
15 June 2017
Quoted from
Abstract
Grade
Peer-reviewed
Document
https://doi.org/10.1161/CIR.0000000000000510
Accessed
2026-11-09
Cited by
Findings citing this exhibit

Cited by

Finding AGR-2.14
Peer-reviewed A 2020 Cochrane review of 15 randomized trials (56,675 participants) found that reducing saturated fat lowered combined cardiovascular events (RR 0.83, 95% CI 0.70-0.98) with little or no effect on all-cause or cardiovascular mortality. A 2017 American Heart Association advisory concluded that replacing saturated fat with mostly refined carbohydrates and sugars is not associated with lower rates of cardiovascular disease.