The Lacuna Project

lacuna (n.) a gap in a record where something should be

Independent research. Not affiliated with any government, agency, or company.

Mechanism

The study not run

A comparison, audit or report that would settle a question, that a responsible body was asked or required to produce, and that does not exist.

Information and Perception

Finding INF-1.16
Open question The filings reviewed do not state how much of each outlet's advertising revenue comes from pharmaceutical advertisers, and no document read shows whether coverage by the stations Nexstar and TEGNA operate changed after the March 2026 waiver. The court order requires Nexstar to hold TEGNA separate and not to influence its management, including newsroom personnel and programming, pending final judgment.
Finding INF-4.7
Open question No public dataset states how many government reports to platforms from 2017 to 2024 led to removal, by agency, platform and administration. The only figure in the record is the FBI agent's recollection of about half.
Finding INF-5.3
Primary record Volume I of the CIA Inspector General's 1998 report found no information that any CIA employee or anyone acting for the CIA had "any direct or indirect dealing with Ricky Ross, Oscar Danilo Blandon or Juan Norwin Meneses." Volume II found that the CIA "acted inconsistently in handling allegations or information" that Contra-related individuals and organizations were involved in drug trafficking, and that it did not inform Congress of eight of ten Contra-related individuals during the fiscal year 1987 statutory prohibition.
Finding INF-5.8
Primary record On 26 May 2021 the President stated that the Intelligence Community had "coalesced around two likely scenarios" and had not reached a definitive conclusion. The Office of the Director of National Intelligence's assessment of 29 October 2021 says all agencies assess natural exposure and a laboratory-associated incident as plausible, that the virus was not developed as a biological weapon, and that most agencies assess with low confidence that it probably was not genetically engineered.

Medicine and Public Health

Finding MED-3.2
Primary record No study has compared children who received the full childhood schedule with children who received none.
Finding MED-3.3
Reported The pivotal trials of the Gardasil vaccines were not compared with an inert placebo. According to ICAN's 2018 reply to HHS, most other vaccines on the current childhood schedule were also licensed against other vaccines or adjuvant-containing controls.
Finding MED-3.5
Primary record The one institutional study to compare vaccinated and unvaccinated children found more chronic disease in the vaccinated, and it was not published.
Finding MED-3.6
Open question A CDC-funded study found an association between vaccine aluminum and childhood asthma. It remains unresolved.
Finding MED-3.7
Open question Studies of 1980s data from Guinea-Bissau found higher infant mortality after DTP vaccination, and no randomized trial has tested the finding.
Finding MED-3.8
Primary record The 1986 Act required HHS to report to Congress periodically, each report covering the preceding two years, on its work toward safer childhood vaccines. In 2018 HHS had no record of any such report.
Finding MED-3.9
Reported In 2025 Pfizer committed to FDA to run a randomized, double-blind, placebo-controlled study of its COVID-19 vaccine in healthy adults aged 50 to 64. In 2026 FDA released Pfizer from a different placebo-controlled commitment from the same approval, a study of post-vaccination syndrome and Long COVID symptoms, and replaced it with a biodistribution study and a retrospective analysis.
Finding MED-3.10
Primary record In a letter of 29 July 2020 answering a request for all CDC documents comparing the health outcomes of children who received vaccines with children who never received any, CDC stated that it "has not conducted a study of health outcomes in vaccinated vs unvaccinated populations."
Finding MED-4.4
Primary record Of 104 accelerated drug approvals with unfinished confirmatory trials in 2022, 35 had a trial past its original completion date. Medicare and Medicaid spent more than $18 billion on the 18 drugs involved from 2018 to 2021.
Finding MED-5.6
Primary record EPA's most recent cancer evaluation of glyphosate was vacated by a federal court in 2022, and EPA has not replaced it.
Finding MED-7.4
Primary record The Institute of Medicine found the evidence inadequate to accept or reject a link between contaminated polio vaccine and cancer. It found strong evidence that SV40 is a transforming virus and contaminated some 1955 to 1963 polio vaccine, and moderate evidence that vaccine exposure caused human SV40 infection.
Finding MED-8.3
Open question Colorectal cancers diagnosed before age 40 carried the mutational signature of a bacterial toxin, colibactin, 3.3 times as often as those diagnosed after 70. The cause of the rise in early-onset cancer has not been established.
Finding MED-8.5
Open question The human studies of glyphosate and non-Hodgkin lymphoma disagree, and the federal cancer evaluation that would weigh them is not expected before 2027.
Finding MED-8.8
Open question Whether SV40 from contaminated polio vaccine caused cancer in people has never been settled.
Finding MED-9.4
Open question No direct, contemporary study measures how many US hospital deaths are preventable. Every national figure is an extrapolation from small, old or foreign samples.
Finding MED-12.5
Primary record GAO found that flawed exposure models undermined federal conclusions about Gulf War chemical-agent exposure and health outcomes.
Finding MED-12.8
Primary record The federal response to the radiation inquiry acknowledged that missing subject identities obstructed individual notification.
Finding MED-13.8
Primary record CDC recognizes persistent symptoms after Lyme treatment and states that their cause remains unknown; NIH has funded research into their biological mechanisms.

War and Defense

Finding DEF-1.4
Primary record Congress required contractors to submit and certify cost or pricing data for negotiated prime contracts expected to exceed $100,000 in 1962. Section 811 of the FY2018 National Defense Authorization Act raised the threshold for contracts awarded on or after 1 July 2018. GAO gives the new figure as $2 million, and the current FAR provision states $2.5 million. GAO reported in 2022 that DoD and NASA had not formally analyzed the effect of the increase.
Finding DEF-3.1
Primary record The DoD Inspector General issued a disclaimer of opinion on the department-wide financial statements in each of fiscal years 2018 through 2025, eight years in a row. GAO reports that DoD is the only one of the 24 Chief Financial Officers Act agencies that has never obtained a clean opinion.
Finding DEF-3.2
Primary record The FY2010 National Defense Authorization Act required the Department of Defense to validate its financial statements as ready for audit by 30 September 2017, and the FY2014 Act required a full audit of the department's fiscal year 2018 statements, with results due to Congress by 31 March 2019.
Finding DEF-3.3
Primary record The DoD Inspector General counted 20 agency-wide material weaknesses in fiscal year 2018, 25 in 2019, 26 in 2020, 28 in each of 2021 through 2024, and 26 in 2025. The Inspector General states that comparing these counts from year to year is not a reliable way to measure progress.
Finding DEF-3.4
Primary record In fiscal year 2025 the DoD Inspector General reported opinions on 21 reporting entities: 11 clean, 1 qualified and 9 disclaimers, up from 5 clean opinions among 21 entities in fiscal year 2018. The Congressional Research Service reports that the entities with disclaimers account for 43 percent of DoD assets.
Finding DEF-3.5
Primary record In 2016 the DoD Inspector General found that the Army and DFAS Indianapolis did not adequately support $2.8 trillion in third-quarter and $6.5 trillion in year-end journal voucher adjustments to fiscal year 2015 Army General Fund data. The report states that the amounts are not cumulative and should not be added together.
Finding DEF-3.8
Primary record GAO could not locate 18 of 96 sampled Air Force equipment items at the Reliance Test & Technology facility at Eglin Air Force Base; in the report body's generalizable sample at that facility the count was 14 of 58. GAO could not locate 58 of 104 sampled items at a second contractor, Standard Aero.
Finding DEF-4.5
Primary record The DoD Inspector General concluded in 2014 that the Department's database of section 847 ethics opinions was "of marginal value" as a management control system. In 2021 GAO recommended that DoD assess adding the lobbying prohibitions to its acquisition regulation, and DoD concurred.
Finding DEF-5.2
Open question No single U.S. government estimate of the total cost of the post-9/11 wars exists.
Finding DEF-5.4
Primary record In January 2017 GAO reported that DoD had an internal estimate of $20 to $30 billion in enduring costs funded through OCO and had not finalized it or reported it outside the department.
Finding DEF-5.5
Primary record The 2011 Institute of Medicine report on open-air burn pits, sponsored by VA, found the data on service members' exposures insufficient to say whether the emissions caused long-term health effects.
Finding DEF-5.7
Primary record VA counted 6,488 veteran suicides in 2024, 44.2 percent of the veterans who died had no VA contact in the year of death or the prior five years, and VA states there is no single comprehensive roster of veterans.
Finding DEF-5.8
Primary record In August 2026 GAO reported that DoD components lacked the staff and technology for the blast-exposure cognitive assessments and the industrial hygiene personnel for the exposure tracking that DoD required in August 2024.
Finding DEF-5.9
Primary record DoD's 2022 Civilian Harm Action Plan states that the U.S. military has not maintained an enterprise-wide, comprehensive database for civilian harm reporting, and in May 2026 the DoD Inspector General found that components fully implemented none of the Plan's objectives by the end of fiscal year 2025.
Finding DEF-5.10
Reported The New York Times reported in December 2021 that, among 1,311 CENTCOM civilian-casualty assessments it obtained, investigators visited the strike site in one and interviewed witnesses or survivors in two.
Finding DEF-6.11
Primary record The Senate Select Committee on Intelligence's 2014 study of the CIA's detention and interrogation program states that Senator Levin's proposal for an independent commission "resulted in concern at the CIA that such a commission would lead to the discovery of videotapes documenting CIA interrogations," that this concern "prompted renewed interest at the CIA to destroy the videotapes," that Levin's amendment failed on 8 November 2005, and that the CIA destroyed the interrogation videotapes the following day.

Politics and Government

Finding POL-6.3
Primary record The DOJ inspector general found in 2016 that DOJ brought seven criminal FARA cases from 1966 to 2015 and had not sought civil injunctive relief since 1991. The audit found that 62 percent of initial registrations were untimely and that the National Security Division does not track FARA cases it declines to prosecute.
Finding POL-6.18
Primary record A February 2019 staff report of the Senate Permanent Subcommittee on Investigations, chaired by Senator Portman (R) with Senator Carper (D) as ranking member, found that 33 of 48 schools required to report Hanban gifts above $250,000 did not, and that $36,089,456 of $51,526,181 that should have been reported for 2012 to 2018 was missing from Education Department data.

Food and Agriculture

Finding AGR-1.4
Primary record GAO reported in 2010 that FDA reviews only the GRAS determinations companies submit, generally has no information about the others, and cannot estimate how many it was not told of. GAO also found that FDA had issued no conflict-of-interest guidance for the expert panels companies convene and did not ask for information on panelists' independence in GRAS notices.
Finding AGR-1.7
Primary record FDA's 2026 economic analysis states that the exact number of substances marketed under independent GRAS conclusions is unknown and assumes 1,000 to 3,000 (primary estimate 2,000), against 1,309 notices filed from February 1998 to March 2025. The proposed rule states that FDA "cannot verify the accuracy of these estimates."

Religious Institutions

No findings in this subject are tagged with this mechanism.